What makes a difference between what matters and what doesn’t is caring. Seems like a small thing, perhaps. Caring that your work is worth doing, that you can make a difference in the world, and that existence has meaning lead you to be engaged in things that matter.
Subjectivity aside, as long as the work is done, the substance of it is a lesser consideration. It will be imbued with your own unique world view and passions. Does it matter? I’d say if you care, it does, and I’m not sure how you create anything for very long without doing so.
We have limited resources. Worthy causes abound. Just as we can only devote so much to helping those in need, we can only give so much to our creative work. We have to choose.
I’d say that it matters less what path or what form that work takes and more that we care about it. Keep caring.